Increased arterial wall stiffness in primary aldosteronism in comparison with essential hypertension
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16942932
DOI
10.1016/j.amjhyper.2006.02.002
PII: S0895-7061(06)00121-X
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Arteries physiopathology MeSH
- Biomarkers blood MeSH
- Vascular Resistance * MeSH
- Adult MeSH
- Hyperaldosteronism physiopathology MeSH
- Hypertension physiopathology MeSH
- Blood Pressure MeSH
- Middle Aged MeSH
- Humans MeSH
- Pulse MeSH
- Blood Flow Velocity MeSH
- Heart Rate MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
BACKGROUND: Aldosterone has been shown to substantially contribute to the accumulation of collagen fibers and growth factors in the arterial wall, which can increase wall stiffness. This study aimed at comparing arterial stiffness between patients with primary aldosteronism (PA), essential hypertension (EH), and normotensive controls using carotid-femoral pulse wave velocity (PWV) and central augmentation index (AI). METHODS: Thirty-six patients with confirmed PA, 28 patients with EH, and 20 normotensive subjects were investigated by Sphygmocor applanation tonometer. RESULTS: The office blood pressure (BP) at the time of the measurement (PA 167+/-34/92+/-12 mm Hg; EH 166+/-19/91+/-10 mm Hg), age, body mass index (BMI), cholesterol, triglyceride, blood glucose levels were comparable between PA and EH groups. The patients with PA had significantly higher PWV than the EH patients and control subjects (9.8+/-2.6 m/sec v 7.5+/-1.0 m/sec v 5.9+/-0.7 m/sec, respectively; all mutual differences P<.001). The difference in PWV between PA and EH remained statistically significant also after the adjustment for all clinical variables including 24-h BP using multivariate analysis (P=.001). CONCLUSIONS: Arterial wall stiffness is independently increased in PA compared to EH. This could be caused by the deleterious effects of aldosterone excess (potentially modulated by hypernatremia) on the fibrosis and remodeling of the arterial wall.
References provided by Crossref.org
The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images
Validation of Existing Clinical Prediction Tools for Primary Aldosteronism Subtyping
Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness
