Changes in proliferation activity and relative distributions of lymphoid cell subpopulations in congenitally athymic nu/nu mice and Lurcher mice with spontaneous olivopontocerebellar degeneration
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17176774
DOI
10.1007/bf02931598
Knihovny.cz E-resources
- MeSH
- Apoptosis MeSH
- Cell Cycle MeSH
- CD4-Positive T-Lymphocytes cytology MeSH
- CD8-Positive T-Lymphocytes cytology MeSH
- Lymph Nodes cytology pathology MeSH
- Lymphocytes cytology MeSH
- Mice, Neurologic Mutants immunology MeSH
- Mice, Nude immunology MeSH
- Mice MeSH
- Adrenal Glands cytology pathology MeSH
- Olivopontocerebellar Atrophies MeSH
- Spleen cytology pathology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Changes observed in mice with congenital damage of some part of the CNS-neuroendocrine-immune regulatory system are described. nu/nu mice with congenital absence of thymus and Lurcher mice with spontaneous olivopontocerebellar degeneration displayed changes in the histoarchitecture of adrenal gland, immune organs (thymus, spleen, axillar lymph nodes) and intestine. Changes were also observed in IgM+, IgG+, CD4+ and CD8+ lymphoid cell subpopulations in the main lymphoid organs--the spleen and axillar lymph nodes and in the proliferative ability of whole lymphoid cell populations. The extreme decrease of lymphoid T-cell subpopulations in athymic nu/nu mice is the consequence of the absence of thymus, the organ of their maturation. On the other hand, a relative increase of B-cell subpopulations was found in this mouse strain. A relative decrease of CD4+ lymphocytes and a different influence of immunization on B-cell subpopulations were found in the spleen in neurodeficient Lurcher mice. The high percentage of apoptotic cells, cells in the S-phase of cell cycle and increased proliferation index in nu/nu mice suggest that the turnover and renewal of lymphoid cells in the spleen in nu/nu mice is more rapid than in control immunocompetent BALB/c mice.
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