Optimization of the high-shear wet granulation wetting process using fuzzy logic modeling
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17763139
DOI
10.1080/10837450701369428
PII: 781508677
Knihovny.cz E-resources
- MeSH
- Chemistry, Pharmaceutical MeSH
- Technology, Pharmaceutical methods MeSH
- Fuzzy Logic * MeSH
- Pharmaceutical Preparations chemistry MeSH
- Excipients chemistry MeSH
- Solubility MeSH
- Wettability MeSH
- Particle Size MeSH
- Water chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Pharmaceutical Preparations MeSH
- Excipients MeSH
- Water MeSH
A fuzzy model has been developed for the optimization of high-shear wet granulation wetting on a plant scale depending on the characteristics of pharmaceutical active substance particles. The model optimized on the basis of experimental data involves a set of rules obtained from expert knowledge and full-scale process data. The skewness coefficient of particle size distribution and the tapped density of the granulated mixture were chosen as the model input variables. The output of the fuzzy ruled system is the optimal quantity of wetting liquid. In comparison to manufacturing practice, a very strong sensitivity of the optimal quantity of the added wetting liquid to the size and shape of the active substance particles has been identified by fuzzy modeling.
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