Effect of adenosine on the growth of human T-lymphocyte leukemia cell line MOLT-4
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17882653
DOI
10.1080/07357900701359973
PII: 782022846
Knihovny.cz E-resources
- MeSH
- Adenosine antagonists & inhibitors metabolism pharmacology MeSH
- Apoptosis MeSH
- Biological Transport drug effects MeSH
- Dipyridamole pharmacology MeSH
- Phosphodiesterase Inhibitors pharmacology MeSH
- Leukemia, T-Cell pathology MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Cell Proliferation drug effects MeSH
- Antineoplastic Agents antagonists & inhibitors metabolism pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adenosine MeSH
- Dipyridamole MeSH
- Phosphodiesterase Inhibitors MeSH
- Antineoplastic Agents MeSH
Adenosine has been observed to suppress the growth of MOLT-4 human leukemia cells in vitro. Changes in the cell cycle, especially increased percentage of cells in S phase, prolonged generation time, and induction of apoptosis at higher adenosine concentrations have been found to be responsible for the growth suppression. Dipyridamole, a drug inhibiting the cellular uptake of adenosine, reversed partially but significantly the adenosine-induced growth suppression. It follows from these results that the action of adenosine on the MOLT-4 cells comprises its cellular uptake and intracellular operation. These findings present new data on anticancer efficacy of adenosine.
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