Failure of multiple antivirals to affect high HHV-6 DNAaemia resulting from viral chromosomal integration in case of severe aplastic anaemia
Language English Country Italy Media print
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
PubMed
18024365
DOI
10.3324/haematol.11592
PII: 92/10/e98
Knihovny.cz E-resources
- MeSH
- Antiviral Agents therapeutic use MeSH
- Anemia, Aplastic drug therapy genetics virology MeSH
- Chromosomes genetics MeSH
- DNA, Viral genetics MeSH
- Drug Therapy, Combination MeSH
- Middle Aged MeSH
- Humans MeSH
- Herpesvirus 6, Human drug effects genetics MeSH
- Drug Resistance, Viral drug effects MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antiviral Agents MeSH
- DNA, Viral MeSH
We report a fifty-year-old woman presenting with severe aplastic anaemia (SAA) and prolonged high Human Herpesvirus 6 (HHV6) variant A DNAeamia detected by quantitative PCR. Multiple antiviral treatments failed to affect the HHV6 DNAemia and subsequent immunosuppressive treatment reached only partial improvement as judged by bone marrow examinations. The patient remained dependent on thrombocyte transfusions and G-CSF treatment. After one year of steady high HHV6 DNA load in blood, viral chromosomal integration was proved by demonstrating the viral DNA in hair follicles. This condition appeared to be unconnected with, and to have no effect, on the original SAA.
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