Absence of ethanol-induced interdigitation in supported phospholipid bilayers on silica surfaces
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18044939
DOI
10.1021/la702346e
Knihovny.cz E-resources
- MeSH
- Adsorption MeSH
- Time Factors MeSH
- Ethanol chemistry MeSH
- Phospholipids chemistry MeSH
- Lipid Bilayers chemistry MeSH
- Membranes, Artificial * MeSH
- Silicon Dioxide chemistry MeSH
- Surface Properties MeSH
- Temperature MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Ethanol MeSH
- Phospholipids MeSH
- Lipid Bilayers MeSH
- Membranes, Artificial * MeSH
- Silicon Dioxide MeSH
Membranes prepared by the adsorption of phospholipid vesicles on solid supports are much-used model systems in biomedical research. However, there is accumulating evidence that such membranes may not always be equivalent to the free-standing cellular membranes that they are modeling. In the present study, sonicated DOPC/DOPS (80/20 mol %) vesicles were adsorbed on hydrophilic silica surfaces, a system that has been demonstrated to produce confluent bilayers. In addition, pure DOPC and DLPC membranes were studied. It is demonstrated that ethanol-induced membrane interdigitation, as demonstrated for free-standing bilayers, does not occur in these supported membranes.
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