Modulation of adrenergic receptors and adrenergic functions in cold adapted humans
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Receptors, Adrenergic drug effects physiology MeSH
- Adrenergic beta-Agonists pharmacology MeSH
- Adrenergic beta-1 Receptor Agonists MeSH
- Adrenergic beta-2 Receptor Agonists MeSH
- Receptors, Adrenergic, beta-1 physiology MeSH
- Receptors, Adrenergic, beta-2 physiology MeSH
- Dobutamine pharmacology MeSH
- Adult MeSH
- Adaptation, Physiological drug effects physiology MeSH
- Infusions, Intravenous MeSH
- Blood Pressure drug effects physiology MeSH
- Humans MeSH
- Metabolism drug effects physiology MeSH
- Cold Temperature * MeSH
- Swimming physiology MeSH
- Oxygen Consumption drug effects physiology MeSH
- Heart Rate drug effects physiology MeSH
- Sympathetic Nervous System drug effects physiology MeSH
- Skin Temperature drug effects physiology MeSH
- Terbutaline pharmacology MeSH
- Thermogenesis drug effects physiology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Receptors, Adrenergic MeSH
- Adrenergic beta-Agonists MeSH
- Adrenergic beta-1 Receptor Agonists MeSH
- Adrenergic beta-2 Receptor Agonists MeSH
- Receptors, Adrenergic, beta-1 MeSH
- Receptors, Adrenergic, beta-2 MeSH
- Dobutamine MeSH
- Terbutaline MeSH
To specify the role of adrenoceptors in mediating adrenergic functions after adaptation of humans to cold, effect of administration of increasing concentrations of beta1 and beta2 adrenomimetics (Dobutamine, Bricanyl) on resting metabolic rate, heart rate, systolic blood pressure, rectal and skin temperatures of control humans and of cold adapted winter swimmers was studied. Increase in metabolic rate, mediated by beta1 and beta2 adrenomimetics, was attenuated after cold adaptation, indicating downregulation of beta1 and beta2 adrenoceptors. Since cold adapted humans have greater capacity of nonshivering thermogenesis, than that mediated by both beta1 and beta2 adrenoceptors, the role of other subtypes of adrenoceptors in mediating nonshivering thermogenesis is anticipated. Heart rate increased after administration of the beta2 agonist, but was not influenced by the beta1 agonist. The significance of beta2 adrenoceptors in mediating heart rate was depressed after cold adaptation. Data indicate that modifications of activity of beta adrenoceptors play crucial role in mechanisms responsible for adaptation of humans to cold.
See more in PubMed
Eur J Appl Physiol. 2000 Aug;82(5-6):439-45 PubMed
J Appl Physiol (1985). 1996 Feb;80(2):616-22 PubMed
Q J Med. 1993 Sep;86(9):595-600 PubMed
Pflugers Arch. 1996 Jul;432(3):368-72 PubMed
Int J Obes Relat Metab Disord. 1993 Dec;17 Suppl 3:S78-81; discussion S82 PubMed
Exp Physiol. 2000 May;85(3):321-6 PubMed
Ann N Y Acad Sci. 1997 Mar 15;813:689-96 PubMed
Biochem J. 1993 Nov 1;295 ( Pt 3):655-61 PubMed
Eur J Appl Physiol Occup Physiol. 1996;74(1-2):148-52 PubMed
Eur J Appl Physiol. 2000 Mar;81(5):436-42 PubMed
Am J Physiol. 1998 Dec;275(6):E909-16 PubMed
J Clin Invest. 1993 Jan;91(1):344-9 PubMed
Rev Endocr Metab Disord. 2001 Oct;2(4):385-93 PubMed
Physiol Bohemoslov. 1967;16(4):366-72 PubMed
Eur J Pharmacol. 2002 Apr 12;440(2-3):99-107 PubMed
Int J Obes Relat Metab Disord. 1995 Sep;19(9):678-85 PubMed
J Appl Physiol (1985). 1987 Apr;62(4):1721-3 PubMed
Trans Assoc Am Physicians. 1981;94:310-3 PubMed
J Therm Biol. 2000 Dec 1;25(6):437-442 PubMed
J Physiol. 1997 Apr 1;500 ( Pt 1):271-82 PubMed
Am J Physiol. 1993 Jan;264(1 Pt 1):E11-7 PubMed
