Metabolic changes in the thalamus after spinal cord injury followed by proton MR spectroscopy
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18219631
DOI
10.1002/mrm.21504
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Choline metabolism MeSH
- Inositol metabolism MeSH
- Creatine metabolism MeSH
- Rats MeSH
- Aspartic Acid analogs & derivatives metabolism MeSH
- Glutamic Acid metabolism MeSH
- Magnetic Resonance Spectroscopy methods MeSH
- Spinal Cord Injuries metabolism MeSH
- Rats, Wistar MeSH
- Protons MeSH
- Thalamus metabolism MeSH
- Hot Temperature MeSH
- Hindlimb physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Choline MeSH
- Inositol MeSH
- Creatine MeSH
- Aspartic Acid MeSH
- Glutamic Acid MeSH
- N-acetylaspartate MeSH Browser
- Protons MeSH
Our study followed the changes in thalamic nuclei metabolism, hindlimb sensitivity to thermal stimulation, and locomotor function after spinal cord injury (SCI). MR spectroscopy (MRS) was used to examine the thalamic nuclei of rats 1 day before and 1, 3, 6, and 15 days after SCI or sham surgery. All animals were tested before MRS measurements for motor performance and thermal sensitivity. SCI induced by balloon compression caused complete paraplegia from the first to third day, followed by partial functional recovery during the second week. MRS revealed an increase in N-acetylaspartate (NAA) concentration in the thalamic nuclei on the first day after SCI, which decreased by the third day. The data also showed an increase in inositol (Ins), glutamate, and creatine (Cr) concentrations on the third day postinjury; the Ins concentration remained elevated on the sixth day. In sham-operated animals an increase in NAA concentration was observed on the sixth and fifteenth days after surgery and an increase in Cr concentration on the third day. A positive correlation between Ins concentration and hindlimb sensitivity in both SCI and sham-operated animals suggests changes in glial activity, while changes in NAA levels may indicate the response of thalamic neuronal cells to injury.
References provided by Crossref.org
