6-Aryl- and 6-heteroarylpurines via cyclotrimerization
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18776489
DOI
10.1093/nass/nrn270
PII: nrn270
Knihovny.cz E-resources
- MeSH
- Cell Line MeSH
- Cytostatic Agents chemical synthesis chemistry pharmacology MeSH
- Diynes chemistry MeSH
- Cobalt chemistry MeSH
- Humans MeSH
- Mice MeSH
- Cell Line, Tumor MeSH
- Nitriles chemistry MeSH
- Purines chemical synthesis chemistry pharmacology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cytostatic Agents MeSH
- Diynes MeSH
- Cobalt MeSH
- Nitriles MeSH
- Purines MeSH
Transition metal complex catalysed cocyclotrimerization of 6-alkynylpurines 1 with various diynes 2 and 6-(diynyl)purines 4 with nitriles 5 enabled to synthesize series of substituted 6-arylpurines 3 and 6-heteroarylpurines 6 in good yields. The obtained 6-aryl- and 6-heteroarylpurines were tested for cytostatic activity.
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