Negative association between plasma levels of adiponectin and polychlorinated biphenyl 153 in obese women under non-energy-restrictive regime
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18825156
DOI
10.1038/ijo.2008.169
PII: ijo2008169
Knihovny.cz E-resources
- MeSH
- Adiponectin blood MeSH
- Biomarkers blood MeSH
- Adult MeSH
- Body Mass Index MeSH
- Insulin blood MeSH
- Caloric Restriction MeSH
- Environmental Pollutants blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Young Adult MeSH
- Obesity blood MeSH
- Polychlorinated Biphenyls blood MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- 2,4,5,2',4',5'-hexachlorobiphenyl MeSH Browser
- Adiponectin MeSH
- Biomarkers MeSH
- Insulin MeSH
- Environmental Pollutants MeSH
- Polychlorinated Biphenyls MeSH
The aim of this study was to reveal whether accumulation of the persistent organic pollutants (POPs), especially polychlorinated biphenyl (2,2',4,4',5,5'-hexachlorobiphenyl, PCB 153), affects plasma levels of adiponectin in obese patients. The study was designed as a longitudinal intervention trial with a control group, where 27 obese women (body mass index (BMI)>30 kg/m(2); age 21-74 years) were studied before (OB) and after (OB-LCD) a 3-month low-calorie-diet intervention (LCD; 5 MJ daily). As the control group, 9 female volunteers without LCD intervention were used (C; BMI=19-25 kg/m(2); age 21-64 years). Plasma levels of PCB 153 were measured by high-resolution gas chromatography with electron capture detection; total adiponectin and insulin plasma levels were quantified by immunoassays; and adiponectin multimeric complexes were quantified by immunoblotting. Plasma levels of total adiponectin, high and medium molecular weight multimers significantly negatively correlated with plasma levels of PCB 153 in OB, but not in C or in OB-LCD, whereas the LCD intervention lowered BMI by 3.3+/-3.0 kg/m(2). Our results may suggest suppression of adiponectin by PCB 153 in obese women under non-energy-restrictive regime, which may contribute to the known association of PCB 153 and other POPs with type 2 diabetes.
References provided by Crossref.org
