Studies on distribution of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chromatography-mass spectrometry
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19261515
DOI
10.1016/j.legalmed.2009.01.021
PII: S1344-6223(09)00031-5
Knihovny.cz E-resources
- MeSH
- Liver chemistry MeSH
- Rats MeSH
- Methamphetamine analogs & derivatives analysis pharmacokinetics MeSH
- Brain Chemistry MeSH
- Designer Drugs pharmacokinetics MeSH
- Lung chemistry MeSH
- Gas Chromatography-Mass Spectrometry MeSH
- Rats, Wistar MeSH
- Forensic Toxicology MeSH
- Central Nervous System Stimulants analysis pharmacokinetics MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 4-methoxymethamphetamine MeSH Browser
- Methamphetamine MeSH
- Designer Drugs MeSH
- Central Nervous System Stimulants MeSH
para-Methoxymethamphetamine (PMMA) is an abused psychedelic compound with reports of several intoxications and deaths after ingestion. However, its pharmacokinetics based on a controlled study is unknown and only partial information on its biotransformation is available. Our experimental study was designed for the time disposition profile of PMMA and its metabolites para-methoxyamphetamine (PMA), para-hydroxymethamphetamine (OH-MAM) and para-hydroxyamphetamine (OH-AM) in blood and biological tissues in rats after the bolus subcutaneous dose 40 mg/kg using a validated GC-MS method. The experimental results ascertained could be useful for subsequent evaluation of PMMA psychotropic or neurotoxic effects and the diagnostic concern of intoxication.
References provided by Crossref.org
