Baclofen dose-dependently disrupts learning in a place avoidance task requiring cognitive coordination
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19344733
DOI
10.1016/j.physbeh.2009.03.024
PII: S0031-9384(09)00145-0
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Baclofen pharmacology MeSH
- Behavior, Animal drug effects MeSH
- GABA Agonists pharmacology MeSH
- Rats MeSH
- Locomotion drug effects MeSH
- Learning Disabilities chemically induced MeSH
- Rats, Long-Evans MeSH
- Spatial Behavior drug effects MeSH
- Reaction Time drug effects MeSH
- Avoidance Learning drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Baclofen MeSH
- GABA Agonists MeSH
The active place avoidance task is a cognitive task requiring spatial learning and cognitive coordination. In this task, animals are trained to move over a continuously rotating arena, on which an imperceptible to-be-avoided sector is defined, remaining stable with respect to the experimental room. The present study was aimed at evaluating the effect of GABA-B receptor agonist baclofen on locomotion and spatial behavior in active place avoidance task. Baclofen (at doses 2, 3, 3.5, 4 and 6 mg/kg) was applied 30 min prior to testing in the task. Doses 2 mg/kg and 3 mg/kg were found not to interfere with either locomotion or spatial avoidance; a dose 3.5 mg/kg disrupted selectively spatial behavior, and doses 4 mg/kg and 6 mg/kg proved to decrease both avoidance efficiency and locomotor activity. It is concluded that GABA-B receptor agonist baclofen dose-dependently disrupts spatial learning and locomotion in the place avoidance task.
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