ANALYSIS OF BAROREFLEX FUNCTION BY MEANS OF MATHEMATICAL MODEL
Status PubMed-not-MEDLINE Language English Country Czech Republic Media print
Document type Journal Article
Grant support
K06 GM013981
NIGMS NIH HHS - United States
PubMed
19424513
PubMed Central
PMC2677721
Knihovny.cz E-resources
- Publication type
- Journal Article MeSH
Re-evaluation of all functions of baroreflex by means of a simple mathematical model of circulation was the aim of the present study. The following states are modelled: 1. Rest. 2. Immediately after baroreceptor denervation. 3. Several days after denervation. 4. Physical exercise before denervation. 5. Physical exercise several days after denervation. Despite the same cardiac contractility and the same vasodilatation in working muscles as before denervation the cardiac output is by one third lower after baroreceptor denervation. In conclusion, a model simulation revealed the common regulation of blood pressure and blood volume by baroreflex and kidneys as a primary function of baroreflex.
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