A comparison of the neuroprotective efficacy of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats
Jazyk angličtina Země Česko Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
19453087
Knihovny.cz E-zdroje
- MeSH
- chemické bojové látky toxicita MeSH
- krysa rodu Rattus MeSH
- neurotoxické syndromy prevence a kontrola MeSH
- organofosforové sloučeniny toxicita MeSH
- oximy chemie terapeutické užití MeSH
- potkani Wistar MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- chemické bojové látky MeSH
- cyclohexyl methylphosphonofluoridate MeSH Prohlížeč
- organofosforové sloučeniny MeSH
- oximy MeSH
The neuroprotective effects of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with cyclosarin were studied. The cyclosarin-induced neurotoxicity was monitored using a functional observational battery 24 hours after cyclosarin challenge. The results indicate that a newly developed oxime K156 is able to counteract slightly cyclosarin-induced neurotoxicity while another newly developed oxime K203 is completely ineffective in reducing cyclosarin-induced neurotoxic signs and symptoms. The neuroprotective efficacy of K156 is comparable with commonly used obidoxime and oxime HI-6. Thus, none of the newly developed oximes achieves better neuroprotective efficacy than both commonly used oximes. They are therefore not suitable replacements for antidotal treatment of acute poisonings with cyclosarin.
