3-Hydroxy-2-phenyl-4(1H)-quinolinones as promising biologically active compounds
Mini reviews in medicinal chemistry.
2009 Jun ;
9 (6) :
696-702.
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Persistent link
https://www.medvik.cz/link/pmid19519495
- MeSH
- Anti-Bacterial Agents chemistry pharmacology MeSH
- Bacteria drug effects MeSH
- Quinolones chemistry pharmacology MeSH
- Inhibitory Concentration 50 MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Antineoplastic Agents chemistry pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Quinolones MeSH
- Antineoplastic Agents MeSH
2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones.
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