Thermoresponsive, hydrolytically degradable polymer micelles intended for radionuclide delivery
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Acrylamides chemistry metabolism MeSH
- Acrylic Resins MeSH
- Biocompatible Materials chemistry metabolism MeSH
- Hydrolysis MeSH
- Drug Delivery Systems MeSH
- Humans MeSH
- Micelles * MeSH
- Molecular Structure MeSH
- Drug Carriers * chemical synthesis chemistry metabolism MeSH
- Polymers * chemical synthesis chemistry metabolism MeSH
- Radioisotopes chemistry metabolism MeSH
- Temperature * MeSH
- Materials Testing MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acrylamides MeSH
- Acrylic Resins MeSH
- Biocompatible Materials MeSH
- Micelles * MeSH
- N-(2-hydroxypropyl)methacrylamide MeSH Browser
- Drug Carriers * MeSH
- poly-N-isopropylacrylamide MeSH Browser
- Polymers * MeSH
- Radioisotopes MeSH
Novel polymer micelles, prepared by self-assembling thermoresponsive poly(N-isopropylacrylamide)-graft-poly[N-(2-hydroxypropyl)methacrylamide] copolymers with hydrolytically degradable N-glycosylamine groups between the polymer blocks are proposed for delivery of diagnostic and therapeutic radionuclides into solid tumors. The micelles are formed by fast heating of an aqueous solution of the copolymer to 37 degrees C. They have a hydrodynamic diameter of 128 nm (measured using dynamic light scattering) and slowly degrade during incubation in aqueous buffer at pH = 7.4. Labeling with both (131)I and (90)Y proceeds with high yields (>85%). The unlabeled polymers are not cytotoxic for any of the tested murine and human cell lines.
References provided by Crossref.org
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