Atypical lipomatous tumors of the tongue: report of six cases
Language English Country Germany Media print-electronic
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cyclin-Dependent Kinase 4 metabolism MeSH
- Child MeSH
- Adult MeSH
- In Situ Hybridization, Fluorescence MeSH
- Tongue pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipoma pathology MeSH
- Liposarcoma metabolism pathology MeSH
- Tongue Neoplasms metabolism pathology MeSH
- S100 Proteins metabolism MeSH
- Proto-Oncogene Proteins c-mdm2 metabolism MeSH
- Aged MeSH
- Vimentin metabolism MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- CDK4 protein, human MeSH Browser
- Cyclin-Dependent Kinase 4 MeSH
- MDM2 protein, human MeSH Browser
- S100 Proteins MeSH
- Proto-Oncogene Proteins c-mdm2 MeSH
- Vimentin MeSH
The occurrence of liposarcoma in the tongue is rare with only 34 cases published so far. We report six new cases of atypical lipomatous tumor (ALT) of the tongue, and detection of mdm-2 and CDK4 expression by immunohistochemistry and fluorescence in situ hybridization (FISH), respectively, was performed. The series comprised three males and three females, aged 11-78 years. The tumors arose at the lateral side of the tongue, and in one case, multiple tumor nodules were noted. Follow-up information in five cases (range from 4 to 159 months) revealed one local recurrence at 6 months. Microscopically, four cases had features of lipoma-like ALT, whereas two cases displayed patterns of sclerosing ALT. Immunohistochemically, tumor cells revealed expression of vimentin (five of five), S100 (five of five), mdm-2 (three of five), and CDK4 (four of five). Two cases were also examined by FISH; amplification of mdm-2 gene was found in both cases, whereas amplification of CDK4 gene was present in one case only. To the best of our knowledge, this is the third largest series reporting occurrence of ALT in the tongue and the first one where analysis of mdm-2 and CDK4 proteins/genes expression/amplification was performed. Both these markers may be of help in the differential diagnosis of ALT versus lipoma. Although most ALTs of the tongue behave in the nonaggressive fashion, they may recur locally. Based on current data, the term ALT is strongly recommended for tumors occurring in the tongue to prevent inadequate treatment.
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