Synthesis of fluorescent C24-ceramide: evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19879139
DOI
10.1016/j.bmcl.2009.10.047
PII: S0960-894X(09)01448-6
Knihovny.cz E-resources
- MeSH
- 4-Chloro-7-nitrobenzofurazan chemical synthesis metabolism MeSH
- Dermatitis, Atopic metabolism MeSH
- Bisbenzimidazole metabolism MeSH
- Ceramides chemical synthesis metabolism MeSH
- Fluorescence MeSH
- Fluorescent Dyes chemical synthesis metabolism MeSH
- Skin metabolism MeSH
- Humans MeSH
- Permeability MeSH
- Psoriasis metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 4-Chloro-7-nitrobenzofurazan MeSH
- Bisbenzimidazole MeSH
- Ceramides MeSH
- Fluorescent Dyes MeSH
Topical skin lipid supplementation may provide opportunities for controlling ceramide (Cer) deficiency in skin diseases such as atopic dermatitis or psoriasis. Here we describe the synthesis of a long-chain 7-nitrobenzo[c][1,2,5]oxadiazol-4-yl (NBD)-labeled Cer and its different penetration through human skin compared to widely used short-chain fluorescent Cer tools.
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