New coupling strategy for radionuclide labeling of synthetic polymers
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20004106
DOI
10.1016/j.apradiso.2009.11.039
PII: S0969-8043(09)00728-3
Knihovny.cz E-resources
- MeSH
- Azo Compounds chemistry MeSH
- Isotope Labeling methods MeSH
- Polymers chemistry MeSH
- Radioisotopes chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Azo Compounds MeSH
- Polymers MeSH
- Radioisotopes MeSH
We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven.
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