Influence of selenium on innate immune response in kids
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Inorganic Chemicals administration & dosage MeSH
- Phagocytosis drug effects MeSH
- Immunologic Factors administration & dosage MeSH
- Goats MeSH
- Organic Chemicals administration & dosage MeSH
- Immunity, Innate drug effects MeSH
- Reactive Oxygen Species metabolism MeSH
- Selenium administration & dosage MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Inorganic Chemicals MeSH
- Immunologic Factors MeSH
- Organic Chemicals MeSH
- Reactive Oxygen Species MeSH
- Selenium MeSH
The effect is described of selenium supplemented in an inorganic and organic form on the innate immune response of goats. Though the phagocytic activity (as a marker of the immune function) was found to be lower in organic-Se-treated group than in control (54.5 +/- 4.32 vs. 60.2 +/- 9.15 %), it did not generally exhibit any significant differences; similarly, no differences were found in the phagocytic index. The production of reactive oxygen species (ROS) was determined using the luminol-enhanced chemiluminescence (CL) (estimated as peak CL, integral CL and a peak time after addition of calcium ionophore A23187, opsonised zymosan (OZP) and phorbol-12-myristate-13-acetate as effectors. A significant ROS increase reflected in integral CL and a peak time was found in the inorganic-Se-treated group when OZP was used as activator; other parameters did not exhibit significant changes. The supplementation of Se in inorganic form can thus be seen to influence positively the innate immune system of kids.
See more in PubMed
Biometals. 1999 Dec;12(4):369-74 PubMed
Phytochemistry. 2008 Feb;69(3):585-606 PubMed
Environ Toxicol Pharmacol. 2008 Jan;25(1):39-42 PubMed
Am J Clin Nutr. 2004 Aug;80(2):410-6 PubMed
Nature. 2004 Feb 26;427(6977):853-8 PubMed
Annu Rev Immunol. 2005;23:197-223 PubMed
Immunol Lett. 1982 Aug;5(2):97-100 PubMed
Anticancer Res. 2004 May-Jun;24(3a):1401-8 PubMed
Physiol Res. 2008;57(3):393-402 PubMed
Anal Bioanal Chem. 2002 Feb;372(3):421-5 PubMed
J Nutr. 2003 May;133(5 Suppl 1):1457S-9S PubMed
Folia Microbiol (Praha). 2003;48(3):417-26 PubMed
Arch Environ Contam Toxicol. 2000 Aug;39(2):243-50 PubMed
