Almost all nutrients in the diet play a crucial role in maintaining an "optimal" immune response, and both insufficient and excessive intakes can have negative consequences on the immune status and susceptibility to a variety of pathogens. We summarize the evidence for the importance of two micronutrients, selenium and zinc, and describe the mechanisms through which they affect the immune status and other physiological functions. As a constituent of selenoproteins, selenium is needed for the proper functioning of neutrophils, macrophages, NK cells, T lymphocytes and some other immune mechanisms. Elevated selenium intake may be associated with reduced cancer risk and may alleviate other pathological conditions including oxidative stress and inflammation. Selenium appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS. It is required for sperm motility and may reduce the risk of miscarriage. Selenium deficiency has been linked to adverse mood states and some findings suggest that selenium deficiency may be a risk factor in cardiovascular diseases. Zinc is required as a catalytic, structural and regulatory ion for enzymes, proteins and transcription factors, and is thus a key trace element in many homeostatic mechanisms of the body, including immune responses. Low zinc ion bioavailability results in limited immunoresistance to infection in aging. Physiological supplementation of zinc for 1-2 months restores immune responses, reduces the incidence of infections and prolongs survival. However, in every single individual zinc supplementation of food should be adjusted to the particular zinc status in views of the great variability in habitat conditions, health status and dietary requirements.

Institute of Immunology Faculty of Medicine Comenius University Institute of Neuroimmunology Slovak Academy of Sciences Bratislava Slovakia

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Arch Gerontol Geriatr. 2001 Nov-Dec;33(3):243-53 PubMed

Immunol Today. 1998 Aug;19(8):342-5 PubMed

Mol Cell Biochem. 1998 Nov;188(1-2):63-9 PubMed

Gen Pharmacol. 1995 Oct;26(6):1153-69 PubMed

Pediatrics. 1998 Jul;102(1 Pt 1):1-5 PubMed

Pharmacol Ther. 1998 Sep;79(3):179-92 PubMed

J Natl Cancer Inst. 1998 Aug 19;90(16):1219-24 PubMed

Br J Urol. 1998 Jul;82(1):76-80 PubMed

Annu Rev Nutr. 1999;19:1-16 PubMed

Br J Rheumatol. 1992 Apr;31(4):281-2 PubMed

Biol Trace Elem Res. 1994 Apr-May;41(1-2):115-27 PubMed

Arch Environ Contam Toxicol. 2000 Aug;39(2):243-50 PubMed

Am J Clin Nutr. 1998 Aug;68(2 Suppl):447S-463S PubMed

Biol Psychiatry. 1991 Jun 1;29(11):1092-8 PubMed

Folia Microbiol (Praha). 2002;47(5):573-8 PubMed

J Nutr. 2000 May;130(5S Suppl):1399S-406S PubMed

Biol Trace Elem Res. 1996 Jun;52(3):241-8 PubMed

J Leukoc Biol. 2002 Jan;71(1):16-32 PubMed

Bibl Nutr Dieta. 2001;(55):148-58 PubMed

Bratisl Lek Listy. 2002;103(1):12-6 PubMed

Eur J Clin Nutr. 1999 Jul;53(7):529-34 PubMed

Mech Ageing Dev. 2000 Dec 20;121(1-3):21-35 PubMed

Am J Clin Nutr. 1991 May;53(5):1288-94 PubMed

Proc Soc Exp Biol Med. 1997 Jul;215(3):229-36 PubMed

Biol Psychiatry. 1996 Jan 15;39(2):121-8 PubMed

Ann Intern Med. 2000 Aug 15;133(4):245-52 PubMed

Clin Infect Dis. 2000 Nov;31(5):1202-8 PubMed

Am J Clin Nutr. 1990 Feb;51(2):225-7 PubMed

J Nutr. 2000 May;130(5S Suppl):1424S-31S PubMed

Lancet. 2000 Jul 15;356(9225):233-41 PubMed

J Infect Dis. 2000 Sep;182 Suppl 1:S62-8 PubMed

Trends Pharmacol Sci. 2000 Jun;21(6):205-8 PubMed

Brain Res Brain Res Rev. 1997 Apr;23(3):219-36 PubMed

Hum Reprod. 1998 Aug;13(8):2172-6 PubMed

Biomed Environ Sci. 1997 Sep;10(2-3):253-9 PubMed

Mutat Res. 2001 Apr 18;475(1-2):123-39 PubMed

J Cardiovasc Risk. 1996 Feb;3(1):42-7 PubMed

J Trace Elem Electrolytes Health Dis. 1994 Mar;8(1):43-7 PubMed

J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):370-4 PubMed

J Obstet Gynaecol. 1997 Mar;17(2):199-200 PubMed

Bratisl Lek Listy. 2002;103(1):17-21 PubMed

Mol Carcinog. 1999 Dec;26(4):213-25 PubMed

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