Synergic activity of selenium and probiotic bacterium Enterococcus faecium M-74 against selected mutagens in Salmonella assay
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
15259772
DOI
10.1007/bf02931047
Knihovny.cz E-zdroje
- MeSH
- antimutagenní látky farmakologie MeSH
- Enterococcus faecium metabolismus fyziologie MeSH
- mutageneze účinky léků MeSH
- mutageny toxicita MeSH
- probiotika farmakologie MeSH
- Salmonella typhimurium účinky léků genetika MeSH
- selen farmakologie MeSH
- synergismus léků MeSH
- testy genotoxicity MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antimutagenní látky MeSH
- mutageny MeSH
- selen MeSH
Concentrated extracts of MRS (De Man-Rogosa-Sharpe) media in which probiotic bacterium Enterococcus faecium strain M-74 was grown exerted different antimutagenic activity against ofloxacin-, N-methyl, N'-nitro-N-nitrosoguanidine- and sodium 5-nitro-2-furylacrylate-induced mutagenicity in Salmonella typhimurium assay depending on the presence (+Se) or absence of disodium selenite pentahydrate (-Se). The antimutagenicity of MRS(+Se) extract was higher than that of MRS(-Se) extract. Selenium enhanced also the antimutagenic effect of both live and killed cells of E. faecium M-74, respectively. The live bacteria decreased the mutagenicity of selected substances more than killed cells. Synergic activity of selenium with the bacterium was also manifested.
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