Synergic activity of selenium and probiotic bacterium Enterococcus faecium M-74 against selected mutagens in Salmonella assay
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15259772
DOI
10.1007/bf02931047
Knihovny.cz E-resources
- MeSH
- Antimutagenic Agents pharmacology MeSH
- Enterococcus faecium metabolism physiology MeSH
- Mutagenesis drug effects MeSH
- Mutagens toxicity MeSH
- Probiotics pharmacology MeSH
- Salmonella typhimurium drug effects genetics MeSH
- Selenium pharmacology MeSH
- Drug Synergism MeSH
- Mutagenicity Tests MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antimutagenic Agents MeSH
- Mutagens MeSH
- Selenium MeSH
Concentrated extracts of MRS (De Man-Rogosa-Sharpe) media in which probiotic bacterium Enterococcus faecium strain M-74 was grown exerted different antimutagenic activity against ofloxacin-, N-methyl, N'-nitro-N-nitrosoguanidine- and sodium 5-nitro-2-furylacrylate-induced mutagenicity in Salmonella typhimurium assay depending on the presence (+Se) or absence of disodium selenite pentahydrate (-Se). The antimutagenicity of MRS(+Se) extract was higher than that of MRS(-Se) extract. Selenium enhanced also the antimutagenic effect of both live and killed cells of E. faecium M-74, respectively. The live bacteria decreased the mutagenicity of selected substances more than killed cells. Synergic activity of selenium with the bacterium was also manifested.
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