Pathogenic microorganisms can be suppressed by cell wall destruction. Biosynthesis of peptidoglycans forming bacterial cell wall is interrupted by glycopeptides which inhibit polymerization of a disaccharide formed by N-acetylglucosamine and N-acetylmuramic acid, beta-lactams and their derivatives inhibit peptidoglycan cross-linking. Antibiotics inhibiting protein synthesis bind to different sites on the rRNA and interfere with the formation of the polypeptide chain. Tumor cells resistant to chemotherapeutic drugs overproduce proteins transporting the drugs out of cells; these proteins eliminate substances which inhibit transcription of transport proteins. Some antitumor drugs (anthracyclines, fluoroquinolones, acridines etc.) act at topoisomerases which irreversibly bind to DNA and inhibit DNA synthesis. Immunosuppressants affect various components of the immune system such as T-helper, T-effector cell function, antigen presentation and B-cell function. Antiparasitics--avermectins--bind to a receptor of this Gab-gated chlorine channel in the nerve fiber of nematodes and anthropodes, increasing the permeability of the membrane for chloride ions; the increased transport of chloride ions into the cell causes the death of the parasite. Ionophores dissolve in phospholipid bilayers and enormously increase their ionic permeability. Respiration inhibitors block the transport of electrons at several places of the respiratory chain. Rifamycin binds to the beta subunit of bacterial RNA polymerase, thereby blocking mRNA synthesis. Antiviral compounds inhibit the transcription of DNA by several mechnisms or by inhibition of viral entry into host cells.

Institute of Microbiology Academy of Sciences of the Czech Republic 142 20 Prague Czechia

Zobrazit více v PubMed

Antimicrob Agents Chemother. 2003 Mar;47(3):837-46 PubMed

Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10594-9 PubMed

J Antibiot (Tokyo). 1998 Mar;51(3):261-6 PubMed

Antimicrob Agents Chemother. 1999 Jun;43(6):1497-9 PubMed

Antimicrob Agents Chemother. 2000 Dec;44(12):3249-56 PubMed

Antimicrob Agents Chemother. 2002 Jun;46(6):1785-92 PubMed

Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8026-33 PubMed

Antimicrob Agents Chemother. 1999 Jul;43(7):1693-9 PubMed

J Antibiot (Tokyo). 1998 Nov;51(11):991-8 PubMed

Antibiot Chemother (Northfield). 1956 Aug;6(8):487-97 PubMed

Antimicrob Agents Chemother. 1999 Feb;43(2):335-40 PubMed

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12 ):6775-9 PubMed

Antimicrob Agents Chemother. 1979 Jun;15(6):747-53 PubMed

J Antibiot (Tokyo). 1995 Jul;48(7):535-48 PubMed

Scand J Rheumatol Suppl. 1992;95:9-18 PubMed

J Antibiot (Tokyo). 1995 Mar;48(3):211-6 PubMed

Eur J Immunol. 1989 Jan;19(1):49-56 PubMed

Antimicrob Agents Chemother. 2001 Jan;45(1):1-12 PubMed

Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60 ; second page, table of contents PubMed

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10617-22 PubMed

J Antibiot (Tokyo). 1999 May;52(5):460-5 PubMed

Antimicrob Agents Chemother. 1999 Jun;43(6):1317-23 PubMed

J Antimicrob Chemother. 2001 Mar;47(3):261-70 PubMed

Folia Microbiol (Praha). 2004;49(6):731-6 PubMed

J Antibiot (Tokyo). 1998 Nov;51(11):1035-9 PubMed

Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7476-81 PubMed

Annu Rev Biochem. 1991;60:191-227 PubMed

Antimicrob Agents Chemother. 2001 Oct;45(10):2813-9 PubMed

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3726-31 PubMed

Antimicrob Agents Chemother. 2001 May;45(5):1522-7 PubMed

Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8045-50 PubMed

Antimicrob Agents Chemother. 1979 Mar;15(3):361-7 PubMed

Antimicrob Agents Chemother. 2003 Jan;47(1):283-91 PubMed

J Bacteriol. 1956 Oct;72(4):561-7 PubMed

J Bacteriol. 1998 Jan;180(2):388-94 PubMed

Biochem Biophys Res Commun. 1990 Dec 31;173(3):1252-7 PubMed

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