Relationship between volatile odorous substances and production of avermectins by Streptomyces avermitilis
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu hodnotící studie, časopisecké články, práce podpořená grantem
PubMed
17571791
DOI
10.1007/bf02932133
Knihovny.cz E-zdroje
- MeSH
- biotechnologie metody MeSH
- fermentace MeSH
- ivermektin analogy a deriváty metabolismus MeSH
- kinetika MeSH
- naftoly metabolismus MeSH
- odoranty analýza MeSH
- plynová chromatografie s hmotnostně spektrometrickou detekcí MeSH
- Streptomyces růst a vývoj metabolismus MeSH
- volatilizace MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- práce podpořená grantem MeSH
- Názvy látek
- avermectin MeSH Prohlížeč
- geosmin MeSH Prohlížeč
- ivermektin MeSH
- naftoly MeSH
The time course of production of odorous compounds, i.e. geosmin and oxolones, and of avermectins was determined during the cultivation of S. avermitilis in flasks, 1- and 50-L fermentors. The amount of the antibiotics increased with increasing cultivation time up to more than 2 g/L while the concentration of geosmin rose to more than 4 mg/L. Cultivation without reflux condenser resulted in a lower product formation due to the higher stripping of geosmin. A relatively tight correlation was found between the production of geosmin and the production of avermectins. The production of oxolones peaked on cultivation days 3-5, the sum of oxolones being 60 microg/L. Subsequently, the production dropped below a measurable level. This can be explained as being due to the inhibition of oxolone production by geosmin.
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