Using the examples of biosynthesis of streptomycin, bialaphos, actinorhodin, oligoketides and autoregulators during the first hours of streptomycete cultivation, it is stressed that the external environment in cooperation with the internal metabolic abilities of the cell determines the metabolic type that would develop during the life cycle of the producing streptomycetes. If we accept that a certain metabolic type (from the point of view of the production of secondary metabolites) was determined already during the first hours of cultivation of the microorganisms, we must also admit that the availability of primary metabolites in the so-called production phase of growth (stationary phase, idiophase, etc.) is to a certain extent determined by the very early stages of strain development.

Institute of Microbiology Academy of Sciences of the Czech Republic Prague Czech Republic

Zobrazit více v PubMed

N Engl J Med. 1991 Feb 28;324(9):601-12 PubMed

Annu Rev Microbiol. 1980;34:209-33 PubMed

FEMS Microbiol Lett. 1993 Jun 15;110(2):239-42 PubMed

Gene. 1994 Aug 19;146(1):47-56 PubMed

Gene. 1992 Jun 15;115(1-2):167-72 PubMed

Trends Biochem Sci. 1990 Oct;15(10):391-5 PubMed

J Bacteriol. 1993 Jul;175(13):4176-85 PubMed

J Bacteriol. 1989 Dec;171(12):6808-14 PubMed

J Bacteriol. 1978 Jun;134(3):1056-63 PubMed

Antibiot Khimioter. 1993 Aug-Sep;38(8-9):3-10 PubMed

J Bacteriol. 1994 Oct;176(19):6107-19 PubMed

J Antibiot (Tokyo). 1993 Jul;46(7):1126-38 PubMed

Res Microbiol. 1994 Feb;145(2):89-92 PubMed

Gene. 1990 Oct 30;95(1):49-56 PubMed

Genes Dev. 1987 Dec;1(10):1305-10 PubMed

J Antibiot (Tokyo). 1980 Feb;33(2):199-204 PubMed

Trends Genet. 1995 Jan;11(1):12-7 PubMed

J Biol Chem. 1992 Sep 25;267(27):19278-90 PubMed

Annu Rev Microbiol. 1978;32:593-636 PubMed

Annu Rev Microbiol. 1989;43:207-33 PubMed

Biotechnol Adv. 1990;8(1):159-83 PubMed

Gene. 1992 Jun 15;115(1-2):5-12 PubMed

J Gen Microbiol. 1985 Apr;131(4):833-47 PubMed

J Gen Microbiol. 1989 Sep;135(9):2465-74 PubMed

Annu Rev Biochem. 1993;62:749-95 PubMed

Microbiol Rev. 1989 Dec;53(4):450-90 PubMed

J Bacteriol. 1981 Nov;148(2):670-7 PubMed

Annu Rev Microbiol. 1993;47:685-713 PubMed

J Bacteriol. 1993 Apr;175(7):1995-2005 PubMed

J Bacteriol. 1990 Aug;172(8):4138-42 PubMed

Annu Rev Microbiol. 1992;46:377-98 PubMed

Folia Microbiol (Praha). 1971;16(3):225-40 PubMed

J Bacteriol. 1983 Sep;155(3):1316-23 PubMed

J Bacteriol. 1996 Mar;178(5):1487-9 PubMed

Nature. 1995 Jun 15;375(6532):549-54 PubMed

Biochimie. 1989 Sep-Oct;71(9-10):1101-5 PubMed

J Bacteriol. 1991 Jul;173(13):4229-33 PubMed

FEMS Microbiol Lett. 1993 May 15;109(2-3):123-9 PubMed

Microbiol Sci. 1988 Aug;5(8):233-5 PubMed

Microbiol Rev. 1980 Jun;44(2):230-51 PubMed

J Bacteriol. 1987 Aug;169(8):3482-8 PubMed

Microbiol Rev. 1986 Jun;50(2):133-65 PubMed

J Bacteriol. 1991 Jul;173(14):4454-63 PubMed

J Gen Microbiol. 1958 Apr;18(2):302-12 PubMed

Mol Microbiol. 1992 Apr;6(8):969-80 PubMed

Mol Microbiol. 1994 Jun;12(5):737-45 PubMed

J Gen Microbiol. 1991 Jul;137(7):1625-34 PubMed

Annu Rev Microbiol. 1989;43:173-206 PubMed

FEMS Microbiol Lett. 1990 Sep 1;59(1-2):145-8 PubMed

Nature. 1994 Sep 22;371(6495):297-300 PubMed

Mol Microbiol. 1992 Oct;6(19):2833-44 PubMed

J Gen Microbiol. 1992 Aug;138 Pt 8:1553-9 PubMed

J Antibiot (Tokyo). 1989 May;42(5):769-78 PubMed

Ciba Found Symp. 1992;171:88-106; discussion 106-12 PubMed

J Bacteriol. 1990 Jun;172(6):3003-8 PubMed

Microbiology (Reading). 1995 Jul;141 ( Pt 7):1739-44 PubMed

Mikrobiologiia. 1979 Nov-Dec;48(6):999-1003 PubMed

Ciba Found Symp. 1992;171:144-56; discussion 156-62 PubMed

FEMS Microbiol Lett. 1994 Feb 15;116(2):131-6 PubMed

Dokl Akad Nauk SSSR. 1967 Nov-Dec;177(1):232-5 PubMed

Annu Rev Microbiol. 1988;42:97-125 PubMed

Pure Appl Chem. 1973;34(3):463-86 PubMed

J Bacteriol. 1994 May;176(9):2694-8 PubMed

Mol Microbiol. 1992 Jul;6(14):2019-29 PubMed

J Bacteriol. 1993 Nov;175(22):7474-8 PubMed

Biotechnology (N Y). 1990 Feb;8(2):115-21 PubMed

Curr Microbiol. 1995 Aug;31(2):84-91 PubMed

J Gen Microbiol. 1993 May;139(5):1003-11 PubMed

Proc Natl Acad Sci U S A. 1983 Sep;80(17):5190-4 PubMed

Gene. 1992 Jun 15;115(1-2):97-103 PubMed

Mol Microbiol. 1993 Mar;7(6):837-45 PubMed

Biotechnol Adv. 1990;8(1):141-58 PubMed

Folia Microbiol (Praha). 1978;23(4):309-28 PubMed

Ciba Found Symp. 1992;171:3-16; discussion 16-23 PubMed

J Bacteriol. 1995 Jun;177(12):3587-8 PubMed

Eur J Biochem. 1984 Dec 3;145(2):381-8 PubMed

Biochem Biophys Res Commun. 1973 May 15;52(2):365-72 PubMed

Biotechnol Adv. 1990;8(1):1-27 PubMed

J Gen Microbiol. 1983 Sep;129(9):2939-44 PubMed

Antimicrob Agents Chemother. 1988 Feb;32(2):282-4 PubMed

J Antibiot (Tokyo). 1994 Jan;47(1):54-63 PubMed

J Gen Microbiol. 1989 Sep;135(9):2475-82 PubMed

Secondary Metabolites Produced during the Germination of Streptomyces coelicolor

Relationship between volatile odorous substances and production of avermectins by Streptomyces avermitilis