Relationship between volatile odorous substances and production of avermectins by Streptomyces avermitilis
Language English Country United States Media print
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
17571791
DOI
10.1007/bf02932133
Knihovny.cz E-resources
- MeSH
- Biotechnology methods MeSH
- Fermentation MeSH
- Ivermectin analogs & derivatives metabolism MeSH
- Kinetics MeSH
- Naphthols metabolism MeSH
- Odorants analysis MeSH
- Gas Chromatography-Mass Spectrometry MeSH
- Streptomyces growth & development metabolism MeSH
- Volatilization MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- avermectin MeSH Browser
- geosmin MeSH Browser
- Ivermectin MeSH
- Naphthols MeSH
The time course of production of odorous compounds, i.e. geosmin and oxolones, and of avermectins was determined during the cultivation of S. avermitilis in flasks, 1- and 50-L fermentors. The amount of the antibiotics increased with increasing cultivation time up to more than 2 g/L while the concentration of geosmin rose to more than 4 mg/L. Cultivation without reflux condenser resulted in a lower product formation due to the higher stripping of geosmin. A relatively tight correlation was found between the production of geosmin and the production of avermectins. The production of oxolones peaked on cultivation days 3-5, the sum of oxolones being 60 microg/L. Subsequently, the production dropped below a measurable level. This can be explained as being due to the inhibition of oxolone production by geosmin.
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