Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: a role in innate immunity?
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20167379
DOI
10.1016/j.jneuroim.2010.01.014
PII: S0165-5728(10)00035-4
Knihovny.cz E-resources
- MeSH
- HLA-E Antigens MeSH
- Glioblastoma immunology physiopathology MeSH
- Gliosis immunology metabolism physiopathology MeSH
- HLA Antigens metabolism MeSH
- HLA-G Antigens MeSH
- Immunomodulation physiology MeSH
- Humans MeSH
- Macrophages immunology metabolism MeSH
- Cell Communication immunology MeSH
- Histocompatibility Antigens Class I metabolism MeSH
- Microglia immunology metabolism MeSH
- Brain immunology metabolism physiopathology MeSH
- Brain Neoplasms immunology physiopathology MeSH
- Cell Movement immunology MeSH
- Immunity, Innate immunology physiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- HLA Antigens MeSH
- HLA-G Antigens MeSH
- Histocompatibility Antigens Class I MeSH
The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of HLA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia-glioblastoma cell interactions with respect to the expression of these molecules deserves further study.
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