Cognitive event-related potentials and oscillations in the subthalamic nucleus
Language English Country Switzerland Media print-electronic
Document type Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't
PubMed
20197697
DOI
10.1159/000289228
PII: 000289228
Knihovny.cz E-resources
- MeSH
- Acoustic Stimulation methods MeSH
- Biophysics MeSH
- Electroencephalography methods MeSH
- Electromyography methods MeSH
- Evoked Potentials physiology MeSH
- Functional Laterality MeSH
- Cognition physiology MeSH
- Humans MeSH
- Neuropsychological Tests MeSH
- Subthalamic Nucleus physiopathology MeSH
- Parkinson Disease complications pathology therapy MeSH
- Periodicity * MeSH
- Psychoacoustics MeSH
- Transcranial Magnetic Stimulation methods MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: The cognitive role of the subthalamic nucleus (STN) remains largely unknown. METHODS/RESULTS: A modified protocol with a dual task elicited local field event-related potentials (ERPs) within the STN. No generators of ERPs were elicited by the standard oddball protocol in the STN (at variance with recordings from the putamen, caudate and pallidum). Repetitive transcranial magnetic stimulation (rTMS) over the right inferior frontal cortex caused a shortening of latencies of ERPs in standard and dual protocols. No changes were observable after the rTMS over the dorsolateral prefrontal cortex and sham stimulation. In the STN, only the tasks with an increased demand on executive functions produced the alpha-/beta-event-related desynchronization/synchronization in visuomotor tasks with single letters writing. CONCLUSION: Our results indicate a specific, task-related involvement of the STN in the cognitive activities. Cognitive processing in the STN is possibly processed via hyperdirect cortico-STN pathway. Certain effects of deep brain stimulation surgery on cognitive performance could be explained by a direct effect on 'cognitive' parts of the STN.
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