Serotype-specific invasive disease potential of Streptococcus pneumoniae in Czech children
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
Wellcome Trust - United Kingdom
PubMed
20508002
DOI
10.1099/jmm.0.018390-0
Knihovny.cz E-zdroje
- MeSH
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- odds ratio MeSH
- pneumokokové infekce epidemiologie mikrobiologie MeSH
- předškolní dítě MeSH
- přenašečství mikrobiologie MeSH
- sérotypizace MeSH
- Streptococcus pneumoniae klasifikace MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
To estimate the invasive disease potential of Streptococcus pneumoniae serotypes, invasive isolates (n=138) were compared with nasopharyngeal isolates (n=153) from children under 6 years of age in the Czech Republic. Odds ratios (ORs) based on a comparison of the distribution of S. pneumoniae serotypes amongst invasive and carriage isolates were calculated for individual serotypes and 172 strains were characterized using multilocus sequence typing. The ORs of serotypes 9V and 14 were significantly greater than 1, suggesting an association with invasive disease, while serotypes 6A and 23F were significantly associated with carriage (ORs less than 1). A single predominant clone with high invasive disease potential was found in each of the 9V, 7F, 14 and 1 serotypes while carriage-associated serotypes were highly heterogeneous.
Citace poskytuje Crossref.org
Paediatric pneumococcal disease in Central Europe
