The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
Wellcome Trust - United Kingdom
PubMed
20520638
DOI
10.1038/leu.2010.104
PII: leu2010104
Knihovny.cz E-resources
- MeSH
- Hematopoiesis physiology MeSH
- Leukemia metabolism pathology MeSH
- Humans MeSH
- Proto-Oncogene Proteins physiology MeSH
- Trans-Activators physiology MeSH
- GATA Transcription Factors physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- proto-oncogene protein Spi-1 MeSH Browser
- Proto-Oncogene Proteins MeSH
- Trans-Activators MeSH
- GATA Transcription Factors MeSH
Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed.
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