Pupilometrie jako bioindikátor úcinku léciv
[Infrared pupilometry as a biomarker of drug effects]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
20662468
- MeSH
- Administration, Oral MeSH
- Adult MeSH
- Infrared Rays MeSH
- Humans MeSH
- Young Adult MeSH
- Analgesics, Opioid administration & dosage pharmacology MeSH
- Pupil drug effects physiology MeSH
- Tramadol administration & dosage pharmacology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Analgesics, Opioid MeSH
- Tramadol MeSH
BACKGROUND: Measurement of the size of the pupil is used as a biomarker of drug efficacy, assessing mainly their effect on the central nervous system. The aim of our study was to evaluate sensitivity of various pupilometric parameters as biomarkers of widely used opioid analgesic drug tramadol. METHODS AND RESULTS: Pharmacodynamic action of tramadol drops given orally in standardized dose of 0.7 mg/kg was studied in 60 healthy volunteers. Commercially available infrared pupilometer Pupilscan II was used for the measurements of static and dynamic pupilometric parameters prior the dosing and 2.5 hours afterwards. Drug-induced decreases of the initial diameter (0.49 mm) and final diameter (0.38 mm) were significant in the right eye, as well as in the left eye. Minimal parameters (0.35 mm) and time to minimum (0.03 mm) were significantly lower after tramadol administration in the left and right eye only. CONCLUSIONS: Our results confirm the use of pupilometry as an objective, non-invasive tool for evaluation of pharmacodynamic activity of drugs.
