Lokální protilátky proti spermiím a celkové hladiny imunoglobulinů v ovulacním cervikálním hlenu
[Local sperm antibodies and general levels of immunoglobulins in ovulatory cervical mucus]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
20925233
- MeSH
- Sperm Agglutination immunology MeSH
- Cervix Mucus immunology MeSH
- Adult MeSH
- Immunoglobulin A, Secretory analysis MeSH
- Immunoglobulin G analysis MeSH
- Humans MeSH
- Young Adult MeSH
- Ovulation * MeSH
- Antibodies analysis MeSH
- Spermatozoa immunology MeSH
- Infertility, Female immunology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Immunoglobulin A, Secretory MeSH
- Immunoglobulin G MeSH
- Antibodies MeSH
OBJECTIVE: The aim of our preliminary study was to compare the levels of total local sIgA and IgG with activity of detected sperm antibodies in ovulatory cervical mucus (OCM). SETTING: Department of Gyneacology and Obstetrics, Medical School and Faculty Hospital, Charles University, Plzen. METHODS: We screened samples of OCM from 12 pacients aged 26-31 (29,6 years on average) by radial immunodifusion (RID) to determine s IgA and IgG. Indirect MAR test was used for detection of spermagglutinationg antibodies. RESULTS: We found out by RID the average concentration of sIgA in OCM 567,84 mg/l (0 -1250,47) and the average concentration of IgG in OCM 23,57 mg/l (8,74-47,99). Antibody activity against sperm cells dominates in IgA with 6 pacients, in IgA with 1 patient, in IgA and IgG together with 1 infertile woman and in IgA and IgM isotypes together with 1 patient. No local sperm antibodies were determined with 3 patients. CONCLUSION: We proved the hypothesis, that the levels of spermagglutinating antibodies do not correlate with findings of total sIgA and IgG in OCM with our patients.
