Fibrin/hyaluronic acid composite hydrogels as appropriate scaffolds for in vivo artificial cartilage implantation
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Biocompatible Materials chemistry MeSH
- Biomechanical Phenomena MeSH
- Chondrocytes cytology physiology MeSH
- Chondrogenesis MeSH
- Cartilage physiology surgery MeSH
- Fibrin chemistry MeSH
- Hydrogels MeSH
- Hyaluronic Acid chemistry MeSH
- Swine, Miniature MeSH
- Swine MeSH
- Prostheses and Implants MeSH
- Regeneration MeSH
- Materials Testing MeSH
- Tissue Engineering MeSH
- Tissue Scaffolds chemistry MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biocompatible Materials MeSH
- Fibrin MeSH
- Hydrogels MeSH
- Hyaluronic Acid MeSH
Hydrogels prepared from a mixture of fibrin and high-molecular weight (MW) hyaluronic acid (HA) were found to be suitable scaffolds for chondrocyte seeding and pig knee cartilage regeneration. Collagen in the hydrogels is not necessary for the formation of biomechanically stable tissue. Regenerated cartilage showed very good biomechanical and histological properties only 6 months after implantation. Notably, the quality of the healing process was dependent on the initial chondrocyte concentration of the scaffolds. These experiments were performed according to good laboratory practice (GLP).
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