Transition from non-surgical heart valve defects repair from bench to bedside is a reality. Some biological material-based designs for transcatheter aortic valve implantation are ready for use. Their drawback, however is their unknown functional as well as structural durability. Moreover, research on new non-biological materials is essential to replace classical animal-derived sources of human heart valve prostheses.

Jan Sochman Clinic of Cardiology Institute for Clinical and Experimental Medicine Videnska 1958 9 140 00 Prague 4 Krc Czech Republic

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