The connexin 37 (1019C>T) gene polymorphism is associated with subclinical atherosclerosis in women with type 1 and 2 diabetes and in women with central obesity
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21208019
DOI
10.33549/physiolres.932039
PII: 932039
Knihovny.cz E-resources
- MeSH
- Obesity, Abdominal genetics MeSH
- Atherosclerosis genetics MeSH
- Diabetes Mellitus, Type 1 complications genetics MeSH
- Diabetes Mellitus, Type 2 complications genetics MeSH
- Genotype MeSH
- Connexins genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Polymorphism, Genetic * MeSH
- Gap Junction alpha-4 Protein MeSH
- Risk Factors MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Connexins MeSH
The gene for connexin 37 (Cx37) is considered to be one of the candidate genes for cardiovascular disease. We evaluated the association between Cx37 (1019C>T) gene polymorphism (Pro319Ser) and ankle brachial blood pressure index (ABI) in women with type 1 (n=178) and type 2 (n=111) diabetes, and in women from general population (n=862). All women were genotyped for Cx37 polymorphism. In addition to traditional cardiovascular risk factors, ABI was analyzed. In women with type 1 diabetes, ABI significantly decreased from TT to CC carriers (p for trend = 0.008). A similar trend was seen in women with type 2 diabetes (p = 0.050) and in women with waist circumference above 75th percentile (94 cm; n=208) of the general population (p = 0.049). The gene for Cx37 was associated with subclinical atherosclerosis in women with type 1 and 2 diabetes and in women with advanced central obesity. The presence of C allele indicated increased risk.
References provided by Crossref.org
The role of connexin 37 polymorphism in spontaneous abortion
