Toxicity of perfluorinated carboxylic acids with carbon chain C(8) to C(12) were tested with oligochaeta Tubifex tubifex. Toxicity was evaluated as the exposure time ET(50) from onset of damage of the oligochaeta in saturated aqueous solutions. The ET(50) fluctuated between 25 and 257 minutes. No statistically significant difference was found among the C(8), C(9) and C(12) acids (ET(50) between 143 and 257 minutes with large standard deviation). The acids with carbon chain C(10) and C(11) induced the effect significantly quicker (25 to 47 minutes). No acute toxicity measured in the three-minute test was observed in any case.

Laboratory of Predictive Toxicology National Institute of Public Health Praha Czech Republic

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Alloatti D, Giannini G, Cabri W, Lustrati I, Marzi M, Ciacci A, Gallo G, Tinti MO, Marcellini M, Riccioni T, Guglielmi P, Pisano C. Synthesis and biological activity of fluorinated Combrestatin analogues. J. Med. Chem. 2008;51:2708–2721. PubMed

Armitage JM, MacLead M, Cousins IT. Comparative assessment of the global fate and transport pathways of long-chain perfluorocarboxylic acids (PFCAs) and perfluorocarboxalates (PFCs) emitted from direct sources. Environ. Sci. Technol. 2009;43:5830–5836. PubMed

Herzke D, Schlabach M, Mariussen E, Uggerud H, Heimstad E. A literature survey on selected chemical compounds. 2007. TA-2238/2007. http://www.sft.no/publikasjoner/2238/ta2238.pdf.

Broxterman HJ, Georgopapadakou NH. Anticancer Therapeutics: “Addictive” multi-targeted drugs, new drug combinations. Drug Resistance Updates. 2005;8:183–197. PubMed

Houde M, Martin JW, Letcher RJ, Solomon KR, Muir DCG. Biological monitoring of polyfluoroalkyl substances: A review. Environmental Science & Technology. 2006;40:3463–3473. PubMed

Kovarova J, Svobodova Z. Perfluorinated compounds: occurrence and risk – A review. Neurotoxicol. Letters. 2008;29:599–608. PubMed

Hariharan R, Bray M, Ganim R, Doenst T, Goodwin GW, Taegtmeyer H. Fundamental limitations of [18F]2-deoxy-2-fluoro-D-glucose for assessing myocardial glucose uptake. Circulation. 1995;91:2435–2444. PubMed

Tichý M, Rucki M. An alternative method for determining acute toxicity of chemicals: cessation of movements in Tubifex tubifex worms. Pracov Lék. 1996;48:225–230. [in czech]

Tichý M, Rucki M, Hanzlíková I, Roth Z. The Tubifex tubifex assay for the determibation of acute toxicity. ATLA. 2007;35:229–237. PubMed

Tichý M, Rucki M, Hanzlíková I, Roth Z. Acute toxicity determination by calculation – Tubifex tubifex assay and quantitative structure – activity relationships. Environ. Toxicol. Chem. 2008;27:2281–2286. PubMed

Valigurova R. Thesis: Toxicity determination of salts of perfluorinated organic acids, Charles University in Prague. 2008.