A feasibility study comparing pharmacist and physician recommendations for sildenafil treatment
Language English Country Netherlands Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
21324090
DOI
10.1111/j.1743-6109.2011.02212.x
PII: S1743-6095(15)33499-8
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Erectile Dysfunction drug therapy MeSH
- Pharmacists standards statistics & numerical data MeSH
- Phosphodiesterase 5 Inhibitors administration & dosage therapeutic use MeSH
- Clinical Competence MeSH
- Practice Patterns, Physicians' standards statistics & numerical data MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Professional Competence MeSH
- Piperazines administration & dosage therapeutic use MeSH
- Cross-Sectional Studies MeSH
- Purines administration & dosage therapeutic use MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Sildenafil Citrate MeSH
- Sulfones administration & dosage therapeutic use MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Geographicals
- Czech Republic MeSH
- Germany MeSH
- Spain MeSH
- United Kingdom MeSH
- Names of Substances
- Phosphodiesterase 5 Inhibitors MeSH
- Piperazines MeSH
- Purines MeSH
- Sildenafil Citrate MeSH
- Sulfones MeSH
INTRODUCTION: In Europe, pharmacists may be an important first point of contact for men with erectile dysfunction (ED) asking for advice and treatment. AIM: To determine if European community pharmacists could appropriately recommend suitability for supply of sildenafil 50 mg for the treatment of ED. METHODS: For this cross-sectional, observational study, the current Summary of Product Characteristics was adapted to create a study drug information sheet for use in a pharmacy setting in which, for certain patients, supply is not suitable and referral to a physician is recommended. After training and with use of a guidance questionnaire, pharmacists assessed the suitability of supply of sildenafil 50 mg for men presenting to their pharmacy. Men with self-reported ED who were not currently using a phosphodiesterase type 5 inhibitor were recruited. Within 7 days of the pharmacist-patient interaction, a physician with experience in the management of ED telephoned the subject to assess suitability. If there was discordance between the pharmacist and physician recommendations, the case was independently reassessed by a physician specialist in sexual medicine. MAIN OUTCOME MEASURES: The primary end point was the concordance rate (with 95% confidence intervals) between pharmacist and physician recommendations. Rates were weighted by country sample sizes. RESULTS: Concordance (95% confidence interval) was 0.70 (0.66-0.74) between pharmacist and physician recommendation, indicating agreement in 70% of cases, and was 0.90 (0.86-0.94) between pharmacist and physician specialist in sexual medicine. Furthermore, if the cases in which the pharmacist did not put subjects at risk (i.e., gave an acceptable recommendation) are assessed, the success rate is 83.5% (79.6-87.4%) and 92.8% (90.1-95.5%), respectively. CONCLUSION: Pharmacists were accurate in providing suitable treatment recommendation, generally not recommending sildenafil for men without ED and recommending physician assessment when there was any question about cardiovascular health, other comorbidity, or co-medication.
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