In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21421582
DOI
10.1093/jac/dkr108
PII: dkr108
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Flavonoids isolation & purification pharmacology MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Oxytetracycline pharmacology MeSH
- Scutellaria chemistry MeSH
- Staphylococcus aureus drug effects MeSH
- Drug Synergism * MeSH
- Tetracycline pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- baicalin MeSH Browser
- Flavonoids MeSH
- Oxytetracycline MeSH
- Tetracycline MeSH
OBJECTIVES: In this study we examined the in vitro synergistic effect of baicalin, the flavone constituent of Scutellaria spp., in combinations with oxytetracycline and tetracycline on the growth of Staphylococcus aureus. METHODS: The MICs were determined by the broth microdilution method and the effect of combinations was evaluated according to the sum of fractional inhibitory concentration indices (FICIs). RESULTS: Synergistic activity (FICI ≤ 0.5) was observed for combinations of baicalin with oxytetracycline or tetracycline against 4 of 10 strains tested, whereas the baicalin/oxytetracycline combination possessed the strongest synergistic effect (FICI = 0.418). CONCLUSIONS: Baicalin acts synergistically with oxytetracycline and tetracycline, enhancing its antimicrobial activity against S. aureus, including methicillin- and tetracycline-resistant strains.
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