In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
21421582
DOI
10.1093/jac/dkr108
PII: dkr108
Knihovny.cz E-zdroje
- MeSH
- antibakteriální látky farmakologie MeSH
- flavonoidy izolace a purifikace farmakologie MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- oxytetracyklin farmakologie MeSH
- šišák chemie MeSH
- Staphylococcus aureus účinky léků MeSH
- synergismus léků * MeSH
- tetracyklin farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antibakteriální látky MeSH
- baicalin MeSH Prohlížeč
- flavonoidy MeSH
- oxytetracyklin MeSH
- tetracyklin MeSH
OBJECTIVES: In this study we examined the in vitro synergistic effect of baicalin, the flavone constituent of Scutellaria spp., in combinations with oxytetracycline and tetracycline on the growth of Staphylococcus aureus. METHODS: The MICs were determined by the broth microdilution method and the effect of combinations was evaluated according to the sum of fractional inhibitory concentration indices (FICIs). RESULTS: Synergistic activity (FICI ≤ 0.5) was observed for combinations of baicalin with oxytetracycline or tetracycline against 4 of 10 strains tested, whereas the baicalin/oxytetracycline combination possessed the strongest synergistic effect (FICI = 0.418). CONCLUSIONS: Baicalin acts synergistically with oxytetracycline and tetracycline, enhancing its antimicrobial activity against S. aureus, including methicillin- and tetracycline-resistant strains.
Citace poskytuje Crossref.org
