Degenerative and inflammatory markers in the cerebrospinal fluid of multiple sclerosis patients with relapsing-remitting course of disease and after clinical isolated syndrome
Language English Country England, Great Britain Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Biomarkers cerebrospinal fluid MeSH
- Nerve Degeneration cerebrospinal fluid pathology MeSH
- Demyelinating Diseases cerebrospinal fluid diagnosis pathology MeSH
- Adult MeSH
- Immunoglobulins cerebrospinal fluid MeSH
- Middle Aged MeSH
- Humans MeSH
- Inflammation Mediators cerebrospinal fluid metabolism MeSH
- Adolescent MeSH
- Young Adult MeSH
- Predictive Value of Tests MeSH
- Nerve Tissue Proteins cerebrospinal fluid MeSH
- Cerebrospinal Fluid Proteins cerebrospinal fluid MeSH
- Multiple Sclerosis, Relapsing-Remitting cerebrospinal fluid diagnosis pathology MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Biomarkers MeSH
- Immunoglobulins MeSH
- Inflammation Mediators MeSH
- Nerve Tissue Proteins MeSH
- Cerebrospinal Fluid Proteins MeSH
BACKGROUND: Literature includes evidence of initial predominance of inflammation and later development of neurodegeneration in the pathogenesis of multiple sclerosis (MS). OBJECTIVE: To search for differences in inflammatory and degenerative cerebrospinal fluid (CSF) markers between relapsing-remitting MS (RRMS) and the clinical isolated syndrome (CIS). METHODS: A total of 148 subjects were evaluated, 65 MS patients (45 RRMS and 20 CIS) and 83 controls. The evaluated parameters included albumin quotient and prealbumin, transferrin, C3 and C4 complement factors, haptoglobin, beta-2-microglobulin, orosomucoid, alpha-1-antitrypsin, apolipoprotein A-I, apolipoprotein B, cystatin C, neuron-specific enolase, tau protein, beta-amyloid, oligoclonal IgG band (OCB), and IgG quotient (QIgG). RESULTS: No differences were found in the inflammatory and degenerative CSF markers between patients with RRMS and CIS. QIgG was higher in RRMS than that in CIS but the number of OCB was higher after CIS. Cystatin C levels were significantly lower in RRMS compared to the other groups. It can be considered an indicator of the demyelination degree. Normal values of beta-amyloid were less frequent in RRMS compared to those in controls.
References provided by Crossref.org
Cerebrospinal fluid inflammatory markers in patients with multiple sclerosis: a pilot study
