Fractional anisotropy and mean diffusivity in the corpus callosum of patients with multiple sclerosis: the effect of physiotherapy
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Anisotropy MeSH
- Corpus Callosum pathology MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Models, Neurological MeSH
- Neuropsychological Tests MeSH
- Image Processing, Computer-Assisted MeSH
- Multiple Sclerosis pathology therapy MeSH
- Case-Control Studies MeSH
- Physical Therapy Modalities * MeSH
- Treatment Outcome MeSH
- Diffusion Tensor Imaging methods MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
INTRODUCTION: Modulation of neurodegeneration by physical activity is an active topic in contemporary research. The purpose of this study was to investigate changes in the brain's microstructure in multiple sclerosis (MS) after facilitation physiotherapy. METHODS: Eleven patients with MS were examined using motor and neuropsychological testing and multimodal MRI at the beginning of the study, with second baseline measurement after 1 month without any therapy, and after a 2-month period of facilitation physiotherapy. Eleven healthy controls were examined at the beginning of the study and after 1 month. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (λ (ax)), and radial diffusivity (λ (rad)) were calculated for the whole corpus callosum (CC) in the midsagittal slice of T1W 3D MPRAGE spatially normalized images. Data were analyzed using linear mixed-effect models, paired, and two-sample tests. RESULTS: At the baseline, patients with MS showed significantly lower values in FA (p < 0.001), and significantly higher values in MD (p < 0.001), λ (ax) (p = 0.003), and λ (rad) (p < 0.001) compared to control subjects. The FA, MD, λ (ax), and λ (rad) did not change between the first and second baseline examinations in either group. Differences 2 months after initiating facilitation physiotherapy were in FA, MD, and in λ (rad) significantly higher than differences in healthy controls (p < 0.001 for FA, p = 0.02 for MD, and p = 0.002 for λ (rad)). In MS patients, FA in the CC significantly increased (p < 0.001), MD and λ (rad) significantly decreased (p = 0.014 and p = 0.002), and thus approached the values in healthy controls. CONCLUSION: The results of the study show that facilitation physiotherapy influences brain microstructure measured by DTI.
See more in PubMed
Ann Neurol. 2000 May;47(5):606-13 PubMed
Neuroimage. 2001 Jun;13(6 Pt 1):1146-54 PubMed
Ann Neurol. 2005 Dec;58(6):840-6 PubMed
J Neurol. 2003 Mar;250(3):287-92 PubMed
Arch Neurol. 2005 Apr;62(4):578-84 PubMed
Brain. 2004 Nov;127(Pt 11):2506-17 PubMed
Mult Scler. 2006 Apr;12(2):227-34 PubMed
J Magn Reson Imaging. 2005 Jun;21(6):735-43 PubMed
Brain. 2008 Feb;131(Pt 2):559-72 PubMed
Exp Brain Res. 2006 Oct;174(4):728-33 PubMed
Restor Neurol Neurosci. 2004;22(3-5):245-60 PubMed
Brain. 1999 May;122 ( Pt 5):871-82 PubMed
Magn Reson Imaging. 2002 Jun;20(5):383-8 PubMed
Exp Brain Res. 2006 Sep;173(4):637-49 PubMed
Curr Opin Neurobiol. 1993 Apr;3(2):187-96 PubMed
Brain Res. 2008 Aug 21;1226:218-25 PubMed
Brain. 2000 Sep;123 ( Pt 9):1845-9 PubMed
Clin Rehabil. 2005 Mar;19(2):170-81 PubMed
J Magn Reson B. 1996 Jun;111(3):209-19 PubMed
Science. 1986 Jun 27;232(4758):1612-9 PubMed
Radiology. 2002 Mar;222(3):729-36 PubMed
Neurology. 1983 Nov;33(11):1444-52 PubMed
Neuroimage. 2005 May 15;26(1):132-40 PubMed
Arch Neurol. 2000 Jul;57(7):1017-21 PubMed
Ann N Y Acad Sci. 2004 Dec;1038:148-70 PubMed
Neuroradiology. 1988;30(6):478-80 PubMed
Radiology. 2007 Nov;245(2):367-84 PubMed
Learn Mem. 2003 Nov-Dec;10(6):456-65 PubMed
Z Orthop Ihre Grenzgeb. 1973 Jun;111(3):268-91 PubMed
Neurol Sci. 2006 Mar;27 Suppl 1:S18-23 PubMed
Mult Scler. 2004 Apr;10(2):182-7 PubMed
Neuroimage. 2005 Feb 15;24(4):1139-46 PubMed
Neurology. 1991 May;41(5):685-91 PubMed
Exp Brain Res. 1991;85(2):417-22 PubMed
Mult Scler. 2004 Aug;10(4):392-7 PubMed
Neuropsychologia. 1971 Mar;9(1):97-113 PubMed
Neurology. 2000 Apr 11;54(7):1421-7 PubMed
Top Stroke Rehabil. 2008 Sep-Oct;15(5):427-50 PubMed
Science. 1985 Apr 12;228(4696):143-9 PubMed
Neuroimage. 2009 Feb 15;44(4):1397-403 PubMed
Ann N Y Acad Sci. 2005 Dec;1064:202-19 PubMed
Brain. 2000 Nov;123 ( Pt 11):2314-20 PubMed
Brain. 2002 Dec;125(Pt 12):2731-42 PubMed
BMC Neurol. 2009 Jul 16;9:34 PubMed
Mult Scler. 2009 Jul;15(7):779-88 PubMed
Arch Neurol. 2005 May;62(5):803-8 PubMed
Funct Neurol. 2009 Oct-Dec;24(4):189-93 PubMed
Hum Brain Mapp. 2007 Jul;28(7):636-44 PubMed
Curr Opin Neurol. 2008 Jun;21(3):272-7 PubMed
Hum Brain Mapp. 2009 Aug;30(8):2656-66 PubMed
Neuroimage. 2002 Nov;17(3):1429-36 PubMed
Neurorehabil Neural Repair. 2010 Jun;24(5):413-9 PubMed
Mult Scler. 2004 Apr;10(2):188-96 PubMed
