Modular synthesis of 1-α- and 1-β-(indol-2-yl)-2'-deoxyribose C-nucleosides
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21785793
DOI
10.1039/c1ob05844d
Knihovny.cz E-resources
- MeSH
- Cyclization MeSH
- Deoxyribose chemical synthesis chemistry MeSH
- Indoles chemical synthesis chemistry MeSH
- Catalysis MeSH
- Nucleosides chemical synthesis chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Deoxyribose MeSH
- Indoles MeSH
- Nucleosides MeSH
A simple two-step method for the selective preparation of anomerically pure 1α- and 1β-(indol-2-yl)deoxyribose derivatives was developed. The synthesis was based on the Sonogashira reaction of 1α- and 1β-ethynyldeoxyribose and 2-haloanilines followed by a Pd-complex catalyzed cyclization to the corresponding indolyldeoxyribosides.
References provided by Crossref.org
Cross-metathesis reaction of α- and β-vinyl C-glycosides with alkenes
