Asoxime (HI-6) impact on dogs after one and tenfold therapeutic doses: assessment of adverse effects, distribution, and oxidative stress
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
21787733
DOI
10.1016/j.etap.2011.03.014
PII: S1382-6689(11)00049-4
Knihovny.cz E-resources
- MeSH
- Acetylcholinesterase metabolism MeSH
- Blood Urea Nitrogen MeSH
- Glutathione blood MeSH
- Glutathione Disulfide blood MeSH
- Hyperglycemia blood chemically induced MeSH
- Creatine Kinase blood MeSH
- Blood Glucose analysis MeSH
- Thiobarbituric Acid Reactive Substances metabolism MeSH
- Oxidative Stress * MeSH
- Oximes administration & dosage blood pharmacokinetics MeSH
- Dogs MeSH
- Pyridinium Compounds administration & dosage blood pharmacokinetics MeSH
- Cholinesterase Reactivators administration & dosage blood pharmacokinetics MeSH
- Sulfhydryl Compounds blood MeSH
- Triglycerides blood MeSH
- Animals MeSH
- Check Tag
- Dogs MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- asoxime chloride MeSH Browser
- Glutathione MeSH
- Glutathione Disulfide MeSH
- Creatine Kinase MeSH
- Blood Glucose MeSH
- Thiobarbituric Acid Reactive Substances MeSH
- Oximes MeSH
- Pyridinium Compounds MeSH
- Cholinesterase Reactivators MeSH
- Sulfhydryl Compounds MeSH
- Triglycerides MeSH
Asoxime (HI-6) is a well known oxime reactivator used for counteracting intoxication by nerve agents. It is able to reactivate acetylcholinesterase (AChE) inhibited even by sarin or soman. The present experiment was aimed to determine markers of oxidative stress represented by thiobarbituric acid reactive substances and antioxidants represented by ferric reducing antioxidant power, reduced and oxidized glutathione in a Beagle dog model. Two groups of dogs were intramuscularly exposed to single (11.4 mg/kg.b.wt.) or tenfold (114 mg/kg.b.wt.) human therapeutically doses of HI-6. HI-6 affinity for AChE in vitro was evaluated in a separate experiment. Complete serum biochemistry and pharmacokinetics were also performed with significant alteration in blood urea nitrogen, creatine phosphokinase, glucose and triglycerides. Blood samples were collected before HI-6 application and after 30, 60, and 120 min. The overall HI-6 impact on organism is discussed.
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