Asoxime (HI-6) impact on dogs after one and tenfold therapeutic doses: assessment of adverse effects, distribution, and oxidative stress
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
21787733
DOI
10.1016/j.etap.2011.03.014
PII: S1382-6689(11)00049-4
Knihovny.cz E-zdroje
- MeSH
- acetylcholinesterasa metabolismus MeSH
- dusík močoviny v krvi MeSH
- glutathion krev MeSH
- glutathiondisulfid krev MeSH
- hyperglykemie krev chemicky indukované MeSH
- kreatinkinasa krev MeSH
- krevní glukóza analýza MeSH
- látky reagující s kyselinou thiobarbiturovou metabolismus MeSH
- oxidační stres * MeSH
- oximy aplikace a dávkování krev farmakokinetika MeSH
- psi MeSH
- pyridinové sloučeniny aplikace a dávkování krev farmakokinetika MeSH
- reaktivátory cholinesterasy aplikace a dávkování krev farmakokinetika MeSH
- sulfhydrylové sloučeniny krev MeSH
- triglyceridy krev MeSH
- zvířata MeSH
- Check Tag
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- acetylcholinesterasa MeSH
- asoxime chloride MeSH Prohlížeč
- glutathion MeSH
- glutathiondisulfid MeSH
- kreatinkinasa MeSH
- krevní glukóza MeSH
- látky reagující s kyselinou thiobarbiturovou MeSH
- oximy MeSH
- pyridinové sloučeniny MeSH
- reaktivátory cholinesterasy MeSH
- sulfhydrylové sloučeniny MeSH
- triglyceridy MeSH
Asoxime (HI-6) is a well known oxime reactivator used for counteracting intoxication by nerve agents. It is able to reactivate acetylcholinesterase (AChE) inhibited even by sarin or soman. The present experiment was aimed to determine markers of oxidative stress represented by thiobarbituric acid reactive substances and antioxidants represented by ferric reducing antioxidant power, reduced and oxidized glutathione in a Beagle dog model. Two groups of dogs were intramuscularly exposed to single (11.4 mg/kg.b.wt.) or tenfold (114 mg/kg.b.wt.) human therapeutically doses of HI-6. HI-6 affinity for AChE in vitro was evaluated in a separate experiment. Complete serum biochemistry and pharmacokinetics were also performed with significant alteration in blood urea nitrogen, creatine phosphokinase, glucose and triglycerides. Blood samples were collected before HI-6 application and after 30, 60, and 120 min. The overall HI-6 impact on organism is discussed.
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