On parameter synthesis by parallel model checking
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21788679
DOI
10.1109/tcbb.2011.110
Knihovny.cz E-resources
- MeSH
- Algorithms * MeSH
- Models, Biological * MeSH
- Nonlinear Dynamics MeSH
- Systems Biology * MeSH
- Computational Biology methods MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
An important problem in current computational systems biology is to analyze models of biological systems dynamics under parameter uncertainty. This paper presents a novel algorithm for parameter synthesis based on parallel model checking. The algorithm is conceptually universal with respect to the modeling approach employed. We introduce the algorithm, show its scalability, and examine its applicability on several biological models.
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