GC/MS analysis of three Amaryllidaceae species and their cholinesterase activity
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21941892
Knihovny.cz E-resources
- MeSH
- Alkaloids chemistry pharmacology MeSH
- Cholinesterase Inhibitors chemistry pharmacology MeSH
- Cholinesterases chemistry metabolism MeSH
- Erythrocyte Membrane enzymology MeSH
- Humans MeSH
- Liliaceae chemistry MeSH
- Gas Chromatography-Mass Spectrometry MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Alkaloids MeSH
- Cholinesterase Inhibitors MeSH
- Cholinesterases MeSH
Alzheimer's disease (AD), characterized by the death of nerve cells in the cerebral cortex, is the most common subtype of dementia. Despite the exponential growth in the number of AD patients, acetylcholinesterase (AChE) inhibitors are currently used to treat AD. Plants of the Amaryllidaceae family are known to synthesize a particular type of bioactive compounds, named Amaryllidaceae alkaloids, which have shown AChE inhibitory activity. Alkaloid extracts of three species of Amaryllidaceae were studied with respect to their acetylcholinesterase and butyrylcholinesterase inhibitory activity and alkaloid patterns. Eleven alkaloids were identified by GC/MS. Significant cholinesterase inhibitory activity was demonstrated by the alkaloid extract of N. undulata (IC50,(HuAChE) = 14.3 +/- 1.2 microg/mL; IC50,(HuBuChE) = 33.9 +/- 1.9 microg/mL).
The Genus Nerine Herb. (Amaryllidaceae): Ethnobotany, Phytochemistry, and Biological Activity
