Differential expression of ABC transporters (MDR1, MRP1, BCRP) in developing human embryos
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- ATP-Binding Cassette Transporters biosynthesis genetics metabolism MeSH
- Embryonic Development genetics physiology MeSH
- Gene Expression MeSH
- Liver embryology MeSH
- Kidney embryology MeSH
- Humans MeSH
- Drug Resistance, Multiple MeSH
- ATP Binding Cassette Transporter, Subfamily B biosynthesis genetics metabolism MeSH
- Intestines embryology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- ATP-Binding Cassette Transporters MeSH
- ATP Binding Cassette Transporter, Subfamily B MeSH
Three ABC transporters (MDR1, MRP1, BCRP), belonging to the family of multidrug resistance (MDR) proteins, play a crucial role in the protection mechanisms during embryogenesis and mediate drug resistance in cancer cells. The distribution of these transporters in the series of human embryonal/fetal intestine, liver and kidneys of various stages of intrauterine development (IUD) by indirect two-step immunohistochemical method was investigated. The organ- and age-specific expression patterns of these transporters were depicted and compared with the expression in adult organs. The evaluation of intestine and liver samples demonstrate differences in expression pattern of ABC transporters during IUD. On the contrary, in kidneys the age-specific localization was not observed. However, the increasing positivity from the kidney surface towards deeper, more differentiated parts was found. Hopefully, our study may contribute to elucidation of the role of multidrug resistance (MDR) pathways during IUD in man.
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