Determination of the antioxidative activity of substituted 5-aminopyrimidines
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Amines chemical synthesis chemistry pharmacology MeSH
- Antioxidants chemical synthesis chemistry pharmacology MeSH
- Hep G2 Cells MeSH
- Rats MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Oxidation-Reduction MeSH
- Lipid Peroxidation drug effects MeSH
- Pyrimidines chemical synthesis chemistry pharmacology MeSH
- Reactive Oxygen Species metabolism MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Amines MeSH
- Antioxidants MeSH
- Pyrimidines MeSH
- Reactive Oxygen Species MeSH
The aminopyrimidine structural motif can be found in diverse biologically active compounds. This study aimed to describe the antioxidant activity of a series of di- and tri-substituted 5-aminopyrimidines using in vitro (TEAC, LPO) and cell-based assays. 2,4,6-trisubstituted 5-aminopyrimidines displayed the highest activity in the TEAC and LPO assays whereas compounds with protected 5-aminogroup were active in the cellular assay. This is most likely because of their better membrane permeability and intracellular metabolic activation. In summary, we have identified the antioxidant activity of a series of substituted 5-aminopyrimidines and their potential prodrugs which may have implications in the treatment of oxidative stress-related diseases.
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