Soluble Toll-like receptor 1 family members in the amniotic fluid of women with preterm prelabor rupture of the membranes
Language English Country Great Britain, England Media print-electronic
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Chorioamnionitis diagnosis microbiology pathology MeSH
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Morbidity MeSH
- Multigene Family MeSH
- Infant, Premature, Diseases diagnosis epidemiology MeSH
- Infant, Newborn MeSH
- Amniotic Fluid chemistry metabolism microbiology MeSH
- Obstetric Labor, Premature diagnosis epidemiology metabolism MeSH
- Fetal Membranes, Premature Rupture diagnosis epidemiology metabolism MeSH
- Predictive Value of Tests MeSH
- Prenatal Diagnosis methods MeSH
- Prognosis MeSH
- Cross-Sectional Studies MeSH
- Solubility MeSH
- Pregnancy MeSH
- Toll-Like Receptor 1 analysis genetics metabolism physiology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Toll-Like Receptor 1 MeSH
OBJECTIVE: To determine soluble Toll-like receptor (sTLR) 1, sTLR2 and sTLR6 concentrations in amniotic fluid (AF) of women with preterm prelabor rupture of membranes (PPROM) and if there is an association with microbial invasion of the amniotic cavity and histological chorioamnionitis (HCA). METHODS: Cross-sectional study was performed. Forty-two women with singleton PPROM pregnancies at a gestational age between 24 + 0 and 36 + 6 weeks were included in the study (twenty-two women with presence of both microbial invasion of the amniotic cavity and HCA, and 20 women without microbial invasion of the amniotic cavity and HCA). Amniocenteses were performed, and the concentrations of sTLRs were determined by sandwich enzyme-linked immunosorbent assays. RESULTS: Women with microbial invasions of the amniotic cavity and HCA (n = 22) had significantly higher median sTLR1, sTLR2 and sTLR6 levels than those without (n = 20). (20.4 ng/mL vs. 0.44 ng/mL; p < 0.0001, 577.6 ng/mL vs. 60.7 ng/mL; p < 0.0001 and 0.44 ng/mL vs. 0.26 ng/mL; p = 0.02, respectively). CONCLUSIONS: Women with microbial invasion of the amniotic cavity and HCA had higher AF sTLR1, 2 and 6 levels.
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